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Department of Cardiovascular Sciences and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester and University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, United Kingdom
Department of Cardiovascular Sciences and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester and University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, United Kingdom
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, LS2 9JT, United KingdomLeeds Institute for Data Analytics, University of Leeds, Leeds, LS2 9JT, United KingdomDepartment of Cardiology, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds, LS1 3EX, United Kingdom
Faculty of Medicine, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, United Kingdom
Department of Cardiovascular Sciences and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester and University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, United Kingdom
The COVID-19 pandemic has resulted in wide-ranging direct and indirect consequences for patients with ACS.
•
A sudden, unexpected decline in hospitalizations for ACS and an increase in out-of-hospital deaths coincided with the onset of the COVID-19 pandemic.
•
ACS in patients with COVID-19 is associated with excess rates of adverse events, particularly when medical intervention is delayed.
•
During the COVID-19 pandemic, many patients with ACS have been required to undergo alternative diagnostic and therapeutic strategies due to reorganization of health care resources.
•
Studies to further elucidate the complex relationship between SARS-CoV-2 infection and myocardial injury or infarction are required.
Introduction
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the most significant infectious disease outbreak and public health emergency for a century. Declared a pandemic by the World Health Organization in March 2020, coronavirus disease 2019 (COVID-19) has infected millions and caused excess mortality and morbidity across the world. Health care systems have been required to restructure and adapt to an entirely novel disease entity, while providing routine and emergency care for existing illness.
Patients with acute coronary syndrome (ACS) provide one such example in which these challenges intersected (Fig. 1). The diagnosis and treatment of acute myocardial infarction (MI) has attracted much scientific attention during the COVID-19 pandemic by virtue of several critical issues:
1.
An internationally observed reduction in hospital admission rates for ACS
The present article addresses these challenges and discusses findings of the International COVID-ACS and UK-ReVasc registries, studies unique in their scope and investigation of the direct and indirect effects of the COVID-19 pandemic on patients with ACS.
COVID-19 and the cardiovascular system: a changing landscape
It rapidly became apparent that the SARS-CoV-2 virus would have wide-reaching consequences for patients with cardiovascular disease, because such risk factor profiles were recognized to portend an increased risk of hospitalization and mortality after infection.
Yet perhaps more unexpected was the sudden and unheralded decline in cases of heart attack observed at the outset of the COVID-19 pandemic. For example, in one of the first such reports, De Filippo and colleagues documented a 25% reduction in hospital admissions for all ACS in Northern Italy.
These data that have since been replicated in larger and more robust analyses that also show preponderance for greater decreases in non–ST-elevation acute coronary syndrome (NSTE-ACS) presentations.
Moreover, increases in out-of-hospital cardiac arrest and death at home when compared with prepandemic periods were described, suggesting that many patients were forgoing medical attention.
Impact of COVID19 pandemic on the incidence and management of out of hospital cardiac arrest in patients presenting with acute myocardial infarction in England.
so why was this not reflected in greater hospital attendances during the initial waves of the pandemic? Proposed theories comprised: (1) a desire from patients to self-manage symptoms at home (perhaps compounded by societal pressures to quarantine), (2) a reduction in activity levels that may provoke MI, or (3) a fear of COVID-19 contagion in health care settings.
Against the backdrop of falling heart attack case rates, a story of the complex interplay between SARS-CoV-2 infection and cardiovascular disease developed, fueled by rapid dissemination of knowledge via social media platforms.
However, the exact degree and frequency of acute myocardial injury in patients with COVID-19, and its relationship with the cardiovascular system, has been difficult to accurately define. In perhaps the most robust study to investigate its prevalence, Lala and colleagues reported acute myocardial injury by means of cardiac troponin elevation in 36% of 2736 patients hospitalized with COVID-19.
Elevated levels correlated with disease severity, as troponin concentrations 3 times the upper reference limit were associated with a 3-fold increased risk of mortality.
Multiple hypotheses have been presented for the direct impact of SARS-CoV-2 on the cardiovascular system, ranging from supply-demand mismatch-mediated ischemia, intravascular thrombosis and endotheliitis, systemic hypoxia, or direct viral insult and injury—each a result of a systemic inflammatory cascade as the SARS-CoV-2 viral spike protein binds to angiotensin-converting enzyme 2 receptors.
Indeed, discrimination between COVID-19–related and non–COVID-19–related myocardial injury has been intensely debated and acknowledged to present significant diagnostic and therapeutic uncertainty for frontline clinicians.
An important group comprises those patients who present with ACS while concurrently infected with COVID-19. Such cases were documented in early observations to experience greater rates of adverse outcomes.
the study was established in March 2020 to elucidate potential mechanisms that may account for the adverse outcomes observed.
The International COVID-ACS Registry has provided a pragmatic means of investigator-initiated data collection via an online web-hosted portal. Lead investigators were cognisant of increased clinical demands, redeployed research personnel, and redistributed funding streams during this period. The criteria for study inclusion were as follows: (1) COVID-19 positive (or high index suspicion according to clinical status and chest imaging findings
Radiological society of North America Expert Consensus Statement on reporting chest CT findings related to COVID-19. Endorsed by the society of Thoracic Radiology, the American College of Radiology, and RSNA - secondary Publication.
) and (2) invasive coronary angiography undertaken for suspected ACS.
A consortium of international investigators collected data from 144 STEMI and 121 NSTE-ACS patients with concomitant COVID-19 infection. The key findings of the study were consistent regardless of ACS subtype (Table 1).
Longer delays seeking medical attention, and, in the case of STEMI, less frequently received timely reperfusion therapy
3.
Higher rates of intensive care unit admission for ventilatory and/or hemodynamic support
4.
Greater adverse in-hospital clinical events, including a more than doubling of cardiogenic shock
5.
A 4-fold increase of in-hospital mortality
Table 1Summary of key findings from the International COVID-ACS registry
Adapted from Kite TA, Ludman PF, Gale CP, et al. International Prospective Registry of Acute Coronary Syndromes in Patients With COVID-19. J Am Coll Cardiol. 2021;77(20):2466-2476.
COVID-STEMI (n = 144)
Pre-COVID-19 STEMI Controls (n = 24,961)
COVID NSTE-ACS (n = 121)
Pre-COVID NSTE-ACS Controls (n = 46,389)
Baseline Characteristics
Mean age, y (SD)
64 (13)
66 (13)
67 (13)
70 (13)
Male
78%
72%
79%
66%
Hypertension
65%
45%
68%
58%
Hyperlipidemia
46%
29%
63%
34%
Diabetes mellitus
34%
21%
39%
31%
Chronic kidney disease
10%
4%
20%
10%
Symptom onset to admission, min (IQR)
339.0 (175.0–1481.5)
173.0 (107.0–387.0)
417.0 (157.0–2904.0)
295.0 (130.0–1021.0)
Door-to-balloon time, min (IQR)
83.0 (37.0–336.0)
37.0 (31.0–109.0)
-
-
Postprocedure
ICU admission
46%
NA
34%
NA
Ventilation
21%
4%
12%
0.4%
Pressor support
27%
5%
19%
0.9%
Mechanical support device
6%
3%
0.8%
0.6%
In-hospital outcomes
Death
23%
6%
7%
1%
Myocardial infarction
6%
NA
4%
NA
Stent thrombosis
1%
NA
0%
NA
Bleeding
3%
0.3%
3%
0.1%
Stroke
2%
0.1%
0.8%
0.1%
Cardiogenic shock
20%
9%
5%
1%
Length of hospital stay, d (IQR)
6.5 (2.7–12.7)
3.0 (2.0–5.0)
6.9 (3.4–18.4)
5.0 (3.0–8.0)
Pre-COVID-19 STEMI controls were taken from the British Cardiovascular Intervention Society 2018 to 2019 National Audit database. Pre-COVID-19 NSTE-ACS controls were taken from the Myocardial Ischaemia National Audit Project 2019 database.
Abbreviations: IQR, interquartile range; NA, data not available; NSTE-ACS, non–ST-elevation acute coronary syndrome; SD, standard deviation; STEMI, ST-elevation myocardial infarction.
These results have been replicated in similar observational studies that have described in-hospital mortality rates of 23% to 33% in COVID-19 positive STEMI patients, and the predilection for SARS-CoV-2 infection in ACS patients with greater baseline comorbidities and of minority ethnic background (Table 2).
Furthermore, elevated rates of unfavorable presenting characteristics such as out-of-hospital cardiac arrest, heart failure, and cardiogenic shock in COVID-19–positive STEMI patients have consistently been described in the literature.
The principal mechanistic finding of the International COVID-ACS Registry was that time taken for patients to render the hospital was prolonged when compared with pre-COVID controls, and that this was associated with poorer clinical outcomes (symptom onset to admission: COVID-STEMI vs controls: median 339.0 minutes vs 173.0 minutes; P < .001; COVID NSTE-ACS vs controls: 417.0 minutes vs 295.0 minutes; P = .012). In addition, a lengthening of door-to-balloon time in the STEMI subgroup was also observed (COVID-STEMI vs controls: median 83.0 minutes vs 37.0 minutes; P < .001). These delays to reperfusion have also been noted in analyses of COVID-19–negative patients hospitalized with STEMI,
thereby suggesting that pathways and well-established systems of care struggled to adapt to the obligatory organizational changes, screening of patients, and preparation of personnel in the catheter laboratory. Such insights in STEMI patients, irrespective of COVID-19 status, provide valuable information and add credence to early hypotheses that deferment in seeking and receiving medical care may, in part, explain the excess mortality rates observed. Public health communications that requested the public “stay at home,” alongside a perceived fear of COVID-19 contagion, appear to have impacted patterns of health care–seeking behavior.
Studies to date have often focused on COVID-19–positive patients with STEMI. The unique scope of the International COVID-ACS registry also afforded insights into patients with NSTE-ACS who underwent an invasive strategy. A striking observation existed that magnitude increases of cardiogenic shock and in-hospital mortality compared with prepandemic controls were similar across both COVID-19–positive ACS subgroups (see Table 1). It is well-established that superior outcomes after STEMI are driven by a time-critical concept dependent on expeditious mechanical reperfusion of an occluded coronary artery. For NSTE-ACS, however, the underlying pathophysiology differs and the association with time from symptom onset to angiography (with or without revascularization) is not nearly as strong when compared with STEMI.
Although limited by a small number of events in the NSTE-ACS group, acceptance that a median time difference of approximately 2 hours until attendance at hospital between COVID-19–positive NSTE-ACS and pre–COVID-19 control patients would result in such marked differences in outcome is initially problematic. Although confounding factors could be at play, in a cohort of patients who carry a greater comorbidity burden (especially those with concomitant COVID-19 in the COVID-ACS registry),
the direct effect of COVID-19 infection could be playing a greater part in this ACS subgroup. Worse outcomes in COVID-19–positive NSTE-ACS patients have been associated with excess thrombogenicity, comparable to reports in COVID-19 positive STEMI cases.
Percutaneous coronary intervention in patients typically treated with coronary artery bypass grafting: the UK-ReVasc registry
Beyond the direct effects of SARS-CoV-2 infection on the global population, the COVID-19 pandemic continues to indirectly impact on mortality and morbidity. Specifically, health care system reorganization, together with changes in patient and clinician behavior, have resulted in restricted access to previously established care pathways, with suggestions that this has led to an increase in deaths from cardiovascular disease.
In particular, reduced availability of intensive care unit support for procedures such as coronary artery bypass grafting (CABG) and valvular surgery resulted in an up to 80% reduction in cardiac surgical activity during the first wave of the COVID-19 pandemic.
In the United Kingdom, National Health Service resources were largely reconfigured to only provide care for emergency cases, with clinicians requested to defer treatment for all other patients in preparation for the expected surge of patients with COVID-19 who would require hospitalization and ventilatory support.
The UK-ReVasc Registry was therefore established as a prospective multicenter registry to investigate the characteristics and outcomes of patients with patterns of coronary artery disease (CAD) that in ordinary circumstances would have been deemed most suitable for CABG surgery,
but who were instead treated with percutaneous coronary intervention (PCI) because of pandemic-enforced constraints on surgical activity and access to ventilators.
The registry reported on 215 patients (75% of whom presented with NSTE-ACS) from across the UK and found in-hospital major adverse cardiovascular events were no different when compared with a conventional pre–COVID-19 all-comer PCI population from the British Cardiovascular Intervention Society (BCIS) National Audit database, despite greater complexity of CAD and a more comorbid population in the UK-ReVasc Registry. Low rates of death, MI, stroke, and unplanned revascularization in the registry population persisted out to 30 days follow-up. When compared with isolated CABG data from the United Kingdom, in-hospital mortality was similar, although lower rates of major bleeding and shorter length of hospital stay were observed in the UK-ReVasc Registry group.
To the best of our knowledge, the UK-ReVasc Registry is the only prospective study that has collected data on this specific and novel patient cohort who were required to undergo an alternative mode of revascularization due to the impact of the COVID-19 pandemic. It affords examination of contemporary PCI techniques in a group of patients with high rates of multivessel disease (96%) and left main stem disease (52%), that according to international guidelines should primarily be reserved for CABG.
Even so, only short-term outcomes have been reported and initial findings perhaps generate more questions than answers. In a population with anatomically complex CAD, does revascularization with contemporary PCI techniques provide comparable and durable longer-term results that are comparable to CABG surgery? Have calcium modification techniques and newer generation drug-eluting stents evolved such that historical revascularization trials require updating to best inform current practice? Longer-term follow-up is required, and ongoing, to inform these important discussions.
Discussion
As we enter the next stages of the COVID-19 pandemic, with decreasing rates of mortality driven by improved therapeutics and mass vaccination strategies, now seems an appropriate juncture to reflect on the impact of this unprecedented crisis. Focus must now shift away from COVID-19 itself and examine the consequences of the SARS-CoV-2 virus on other areas of health service delivery and care.
Cardiovascular disease remains the leading cause of morbidity and mortality globally and is associated with 17.8 million deaths annually.
Patients with cardiovascular disease have been one of the hardest hit groups during the pandemic period, directly because of SARS-CoV-2 predilection to cause severe infection and death in people with such comorbidities, but also indirectly because of restricted availability and access to routine and urgent health care provision that is recognized to improve clinical outcomes.
Governments and public health institutions mandated their citizens to stay at home and reduce social interaction to avoid contagion, particularly those of older age and at high risk of complications after SARS CoV-2 infection.
For instance, surges in mechanical complications after ACS have been described during the pandemic, with reports of ventricular septal and free wall rupture,
Perhaps the most noteworthy impact of the pandemic has yet to be quantified. Concerns regarding the provision of care for noncommunicable diseases such as cardiovascular disease and cancer have been raised, but arguably overlooked because of the imminent threat of COVID-19–positive patients overwhelming acute hospitals. Although some patients were able to undergo an alternative treatment strategy, many have been left struggling to access timely and appropriate health care. Analyses from electronic health record and mortality in England estimate that up to 100,000 excess deaths from indirect effects of the COVID-19 pandemic have occurred in patients with cardiovascular disease, predominantly due to reduced supply of, and demand for, cardiac services.
Beyond this, we are only beginning to see the repercussions of delayed and suboptimal revascularization in patients with ACS that will lead to larger infarct size, adverse ventricular remodeling, heart failure, and arrhythmias.
Despite the immeasurable suffering caused by COVID-19, it remains remarkable that in the face of adversity health care systems and professionals have remained resilient despite these unprecedented challenges. The 2 multicenter registries presented in this report are examples of the clinical and research communities collaborating to better understand the implications of COVID-19 for patients with ACS. Despite the stark messages delivered, they highlight areas that require further focus and investigation to ensure improved care for our patients. Future concerted research initiatives, support from national political leaders, and robust public education campaigns are therefore required to ameliorate the adverse direct and indirect impact caused by the ongoing COVID-19 pandemic.
Summary
The COVID-19 pandemic has proven a “double threat” to patients with ACS. First, the complex interplay of direct SARS-CoV-2 infection, diagnostic uncertainty in the acute setting, and time delays to hospital in this population have contributed to excess morbidity and mortality. Second, a shift of attention and resource from established service pathways to focus on the surges of COVID-19–positive patients requiring emergency care has required modification of traditionally accepted treatment approaches. Given recent acknowledgment that SARS-CoV-2 endemicity is now inevitable,
improved public health messaging and adaptation of existing health care systems to provide optimal treatment to both COVID-19 and non–COVID-19 patients is required. Future clinical research initiatives to better understand the COVID-19 and multiple mechanistic factors at play in patients with ACS are essential.
Tribute to Professor Tony Gershlick
Finally, this article would be incomplete without remembrance of Professor Tony Gershlick, pioneer interventional cardiologist, esteemed clinical trialist, revered mentor, and friend to many who died of COVID-19 in November 2020. The chief investigator of both the COVID-ACS and UK-ReVasc registry studies, Tony’s passion for research over a long and distinguished career has resulted in a remarkable impact on cardiovascular care in the United Kingdom and beyond.
Clinics care points
This article focuses on the indirect and direct effects of the COVID-19 pandemic on the diagnosis, treatment, and outcomes of patients with ACS. The following points should be considered by care providers when approaching this important patient population:
•
In COVID-19–positive patients, discrimination between ACS and acute myocardial injury is a challenge. In hospitalized COVID-19 patients, elevated cardiac enzymes occur in approximately one-third and portend an increased risk of morbidity and mortality.
•
Patients with ACS are more likely to experience delays in receipt of timely care during the COVID-19 pandemic because of changes in health care–seeking behavior and care pathway modifications.
•
As compared with pre–COVID-19 cohorts, STEMI and NSTE-ACS patients with concomitant COVID-19 infection experience greater rates of in-hospital bleeding, stroke, cardiogenic shock, and mortality. Delayed medical intervention appears to be a significant mechanistic factor.
•
Owing to the indirect effect of the COVID-19 pandemic on health care delivery, many patients with ACS have undergone alternative revascularization strategies (eg, PCI rather than CABG). Short-term outcomes are robust but follow-up of such cohorts is necessary to establish whether long-term clinical outcomes are acceptable.
•
The direct and indirect effects of the COVID-19 pandemic on patients with ACS have yet to be precisely defined. Future investigations should aim to understand the complex interplay of SARS-CoV-2 infection and MI. Understanding and addressing the indirect impact of COVID-19 on patients with established cardiovascular disease is of critical importance to optimize care and improve outcomes.
Disclosure
C.P. Gale reports personal fees from AstraZeneca, Amgen, Bayer, Boehringer-Ingelheim, Daiichi Sankyo, Vifor Pharma, Menarini, Wondr Medical, Raisio Group, and Oxford University Press; grants from BMS, Abbott, British Heart Foundation, National Institute for Health Research, Horizon 2020, and ESC, outside the submitted work. N. Curzen reports unrestricted research grants from Boston Scientific, HeartFlow, and Beckman Coulter, and speaker/consultancy fees from Boston, Abbott, and HeartFlow outside the submitted work. The remaining authors have no conflicts of interest to declare.
References
Mafham M.M.
Spata E.
Goldacre R.
et al.
COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England.
Impact of COVID19 pandemic on the incidence and management of out of hospital cardiac arrest in patients presenting with acute myocardial infarction in England.
Radiological society of North America Expert Consensus Statement on reporting chest CT findings related to COVID-19. Endorsed by the society of Thoracic Radiology, the American College of Radiology, and RSNA - secondary Publication.
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