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Review Article| Volume 19, ISSUE 1, P75-87, January 2023

Pregnancy and Pulmonary Hypertension

From Preconception and Risk Stratification Through Pregnancy and Postpartum

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      Reference

        • Martin S.R.
        • Edwards A.
        Pulmonary Hypertension and Pregnancy.
        Obstet Gynecol. 2019; 134: 974-987
        • George M.G.
        • Schieb L.J.
        • Ayala C.
        • et al.
        Pulmonary hypertension surveillance. United States, 2001 to 2010.
        Chest. 2014; 146: 476-495
        • Bedard E.
        • Dimopoulos K.
        • Gatzoulis M.A.
        Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?.
        Eur Heart J. 2009; 30: 256-265
        • Weiss B.M.
        • Zemp L.
        • Seifert B.
        • et al.
        Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996.
        J Am Coll Cardiol. 1998; 31: 1650-1657
        • Regitz-Zagrosek V.
        • Blomstrom Lundqvist C.
        • Borghi C.
        • et al.
        ESC guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC).
        Eur Heart J. 2011; 32: 3147-3197
        • Thomas E.
        • Yang J.
        • Xu J.
        • et al.
        Pulmonary hypertension and pregnancy outcomes: insights from the national inpatient sample.
        J Am Heart Assoc. 2017; 6: 1-12
        • Henshaw S.K.
        Unintended pregnancy in the United States.
        Fam Plann Perspect. 1998; 30 (46): 24-29
        • Galiè N.
        • Humbert M.
        • Vachiery J.L.
        • et al.
        2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
        Eur Heart J. 2016; 37: 67-119
        • Simonneau G.
        • Montani D.
        • Celermajer D.S.
        • et al.
        Haemodynamic definitions and updated clinical classification of pulmonary hypertension.
        Eur Respir J. 2019; 53: 1-13
        • Liu S.
        • Elkayam U.
        • Naqvi T.Z.
        Echocardiography in pregnancy: part 1.
        Curr Cardiol Rep. 2016; 18: 92
        • Penning S.
        • Robinson K.D.
        • Major C.A.
        • et al.
        A comparison of echocardiography and pulmonary artery catheterization for evaluation of pulmonary artery pressures in pregnant patients with suspected pulmonary hypertension.
        Am J Obstet Gynecol. 2001; 184: 1568-1570
        • Wylie B.J.
        • Epps K.C.
        • Gaddipati S.
        • et al.
        Correlation of transthoracic echocardiography and right heart catheterization in pregnancy.
        J Perinat Med. 2007; 35: 497-502
      1. American College of Obstetricians and Gynecologists' Presidential Task Force on Pregnancy and Heart Disease and Committee on Practice Bulletins—Obstetrics. ACOG Practice Bulletin No. 212: Pregnancy and Heart Disease.
        Obstet Gynecol. 2019; 133: e320-e356
        • Sanghavi M.
        • Rutherford J.D.
        Cardiovascular physiology of pregnancy.
        Circulation. 2014; 130: 1003-1008
        • Nama V.
        • Antonios T.F.
        • Onwude J.
        • et al.
        Mid-trimester blood pressure drop in normal pregnancy: myth or reality?.
        J Hypertens. 2011; 29: 763-768
        • Kinsella S.M.
        • Lohmann G.
        Supine hypotensive syndrome.
        Obstet Gynecol. 1994; 83: 774-788
        • Kuhn J.C.
        • Falk R.S.
        • Langesaeter E.
        Haemodynamic changes during labour: continuous minimally invasive monitoring in 20 healthy parturients.
        Int J Obstet Anesth. 2017; 31: 74-83
        • Sibai B.M.
        Etiology and management of postpartum hypertension-preeclampsia.
        Am J Obstet Gynecol. 2012; 206: 470-475
        • Castro L.C.
        • Hobel C.J.
        • Gornbein J.
        Plasma levels of atrial natriuretic peptide in normal and hypertensive pregnancies: a meta-analysis.
        Am J Obstet Gynecol. 1994; 171: 1642-1651
        • Ducas R.A.
        • Elliott J.E.
        • Melnyk S.F.
        • et al.
        Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study.
        J Cardiovasc Magn Reson. 2014; 16: 1
        • Melchiorre K.
        • Sharma R.
        • Khalil A.
        • et al.
        Maternal cardiovascular function in normal pregnancy: evidence of maladaptation to chronic volume overload.
        Hypertension. 2016; 67: 754-762
      2. Hameed A, Foster E, Main E, et al. Cardiovascular disease assessment in pregnant and postpartum women, a California maternal quality care collaborative quality Improvement Toolkit, 2017.

      3. Thromboembolism in pregnancy. ACOG Practice Bulletin No. 196. American College of Obstetricians and Gynecologists.
        Obstet Gynecol. 2018; 132: e1-e17
        • Meng M.L.
        • Landau R.
        • Viktorsdottir O.
        • et al.
        Pulmonary hypertension in pregnancy: a report of 49 cases at four tertiary North American sites.
        Obstet Gynecol. 2017; 129: 511-520
        • Low T.T.
        • Guron N.
        • Ducas R.
        • et al.
        Pulmonary arterial hypertension in pregnancy-a systematic review of outcomes in the modern era.
        Pulm Circ. 2021; 11 (20458940211013671)
        • Kovacs A.H.
        • Harrison J.L.
        • Colman J.M.
        • et al.
        Pregnancy and contraception in congenital heart disease: what women are not told.
        J Am Coll Cardiol. 2008; 52: 577-578
        • Galiè N.
        • Channick R.N.
        • Frantz R.P.
        • et al.
        Risk stratification and medical therapy of pulmonary arterial hypertension.
        Eur Respir J. 2019; 53: 1-11
        • Chin K.M.
        • Channick R.N.
        Pulmonary hypertension.
        in: Broaddus V.C. Mason R.J. Ernst J.D. Murray and Nadel's textbook of respiratory medicine. 6th ed. Elsevier, Philadelphia, PA2016: 1031-1049
        • Hemnes A.R.
        • Kiely D.G.
        • Cockrill B.A.
        • et al.
        Statement on pregnancy in pulmonary hypertension from the pulmonary vascular research institute.
        Pulm Circ. 2015; 5: 435-465
        • Del Pozo R.
        • Hernandez Gonzalez I.
        • Escribano-Subias P.
        The prostacyclin pathway in pulmonary arterial hypertension: a clinical review.
        Expert Rev Respir Med. 2017; 11: 491-503
        • Bonnin M.
        • Mercier F.J.
        • Sitbon O.
        • et al.
        Severe pulmonary hypertension during pregnancy: mode of delivery and anesthetic management of 15 consecutive cases.
        Anesthesiology. 2005; 102: 1133-1137
        • Bendayan D.
        • Hod M.
        • Oron G.
        • et al.
        Pregnancy outcome in patients with pulmonary arterial hypertension receiving prostacyclin therapy.
        Obstet Gynecol. 2005; 106: 1206-1210
        • Briggs G.G.
        • Freeman R.K.
        • Towers C.V.T.
        • et al.
        Drugs in pregnancy and lactation, a reference guide to fetal and neonatal risk.
        11th edition. Wolters Kluwer, Philadelphia, PA2017
        • Stout K.K.
        • Daniels C.J.
        • Aboulhosn J.A.
        • et al.
        2018 AHA/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
        Circulation. 2018; 139 ([Epub ahead of print]): e698-e800
        • Kiely D.G.
        • Condliffe R.
        • Webster V.
        • et al.
        Improved survival in pregnancy and pulmonary hypertension using a multiprofessional approach.
        BJOG. 2010; 117: 565-574
        • Sliwa K.
        • van Hagen I.M.
        • Budts W.
        • et al.
        ROPAC investigators. Pulmonary hypertension and pregnancy outcomes: data from the Registry of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology.
        Eur J Heart Fail. 2016; 18: 1119-1128
        • Jais X.
        • Olsson K.M.
        • Barbera J.A.
        • et al.
        Pregnancy outcomes in pulmonary arterial hypertension in the modern management era.
        Eur Respire J. 2012; 40: 881-885
        • Sahni S.
        • Palkar A.V.
        • Rochelson B.L.
        • et al.
        Pregnancy and pulmonary arterial hypertension: a clinical conundrum.
        Pregnancy Hypertens. 2015; 5: 157-164
        • Sangkum L.
        • Liu G.L.
        • Yu L.
        • et al.
        Minimally invasive or noninvasive cardiac output measurement: an update.
        J Anesth. 2016; 30: 461-480
        • O'Hare R.
        • McLoughlin C.
        • Milligan K.
        • et al.
        Anaesthesia for caesarean section in the presence of severe primary pulmonary hypertension.
        Br J Anaesth. 1998; 81: 790-792
        • Yuan S.
        Eisenmenger syndrome in pregnancy.
        Braz J Cardiovasc Surg. 2016; 31: 325-329
        • Konstantinides S.V.
        Trends in pregnancy outcomes in patients with pulmonary hypertension: still a long way to go.
        Eur J Heart Fail. 2016; 18: 1129-1130
        • Caughey A.B.
        • Cahill A.G.
        • et al.
        • American College of Obstetricians and Gynecologists (College); Society for Maternal-Fetal Medicine
        Safe prevention of the primary cesarean delivery.
        J Obstet Gynecol. 2014; 210: 179-193
        • Sharma K.
        • Afshar Y.R.
        • Bairey-Merz C.N.
        • et al.
        Guidelines and consensus: statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute.
        Pulm Circ. 2016; 6: 143