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References
- Current and future treatments of pulmonary arterial hypertension.Br J Pharmacol. 2021; 178: 6-30
- Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?.Am J Respir Crit Care Med. 2022; 205: 751-760
- Assembly and function of small RNA - argonaute protein complexes.Biol Chem. 2014; 395: 611-629
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation.Front Endocrinol (Lausanne). 2018; 9https://doi.org/10.3389/FENDO.2018.00402
- MicroRNAs in cardiovascular diseases: Current knowledge and the road ahead.J Am Coll Cardiol. 2014; 63: 2177-2187
- MicroRNAs in cardiovascular disease: an introduction for clinicians.Heart. 2015; 101: 921-928
- Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunities.Wiley Interdiscip Rev RNA. 2020; 11: e1563
- Noncoding RNAs: Classification, Biology and Functioning.Adv Exp Med Biol. 2016; 937: 3-17
- MicroRNAs in development and disease.Physiol Rev. 2011; 91: 827-887
- Modulation of miRNAs in Pulmonary Hypertension.Int J Hypertens. 2015; 2015https://doi.org/10.1155/2015/169069
- Therapeutic implications of microRNAs in pulmonary arterial hypertension.BMB Rep. 2014; 47: 311-317
- MicroRNAs in flow-dependent vascular remodelling.Cardiovasc Res. 2013; 99: 294-303
- Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis mechanosensitive athero-miRs.Arterioscler Thromb Vasc Biol. 2014; 34: 2206-2216
- MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment.J Am Soc Hypertens. 2015; 9: 221-234
- MicroRNA-27b plays a role in pulmonary arterial hypertension by modulating peroxisome proliferator-activated receptor γ dependent Hsp90-eNOS signaling and nitric oxide production.Biochem Biophys Res Commun. 2015; 460: 469-475
- Mechanistic insights into the link between a polymorphism of the 3’UTR of the SLC7A1 gene and hypertension.Hum Mutat. 2009; 30: 328-333
- Identification of a novel polymorphism in the 3’UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.Circulation. 2007; 115: 1269-1274
- Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase.Hypertension. 2012; 60: 1407-1414
- Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells.Circ Res. 2007; 100: 1164-1173
- Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.Am J Hum Genet. 2000; 67: 737-744
- Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation.The EMBO J. 2011; 30: 4450
- AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension.Eur Heart J. 2014; 35: 3203-3211
Pullamsetti SS, Doebele C, Fischer A, et al. Inhibition Of MicroRNA-17 Improves Lung And Heart Function In Experimental Pulmonary Hypertension. 2012:A2617-A2617. doi:10.1164/AJRCCM-CONFERENCE.2012.185.1_MEETINGABSTRACTS.A2617
- Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.J Clin Invest. 2014; 124: 3514-3528
- Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges.JACC Basic Transl Sci. 2020; 5: 1149-1162
- Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.Am J Respir Crit Care Med. 2016; 194: 1273-1285
- Role for miR-204 in human pulmonary arterial hypertension.J Exp Med. 2011; 208: 535-548
- Mir-206 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Differentiation.PLoS ONE. 2012; 7https://doi.org/10.1371/JOURNAL.PONE.0046808
- MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension through targeting of the HIF-1α/Fhl-1 pathway.Lab Invest. 2013; 93: 748-759
- miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling.Am J Physiol Lung Cell Mol Physiol. 2012; 302: 521-529
- SMAD proteins control DROSHA-mediated microRNA maturation.Nature. 2008; 454: 56-61
- MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.Circulation. 2012; 125: 1520-1532
- Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.Arterioscler Thromb Vasc Biol. 2010; 30: 716-723
- MicroRNA-138 plays a role in hypoxic pulmonary vascular remodeling by targeting Mst1.Biochem J. 2013; 452: 281-291
- Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction.FEBS Lett. 2014; 588: 906-914
- An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.Nat Med. 2012; 19: 74-82
- Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.Nat Cell Biol. 2012; 14: 249-256
- TGFβ triggers miR-143/145 transfer from smooth muscle cells to endothelial cells, thereby modulating vessel stabilization.Circ Res. 2015; 116: 1753-1764
- MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.Circ Res. 2009; 105: 158-166
- A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples.Circ Res. 2012; 111: 290-300
- MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells.J Biol Chem. 2013; 288: 25414-25427
- MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.Circ Res. 2014; 114: 67-78
- The multidimensional mechanisms of long noncoding RNA function.Genome Biol. 2017; 18
- The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.Genome Res. 2012; 22: 1775-1789
- The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis.Int J Mol Sci. 2021; 22: 1-20
- N6-methyl-adenosine modification in messenger and long noncoding RNA.Trends Biochem Sci. 2013; 38: 204-209
- Decapping of long noncoding RNAs regulates inducible genes.Mol Cell. 2012; 45: 279-291
- Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively.Mol Cell Biol. 1997; 17: 6122-6130
- Long noncoding RNA review and implications in acute lung inflammation.Life Sci. 2021; 269https://doi.org/10.1016/j.lfs.2021.119044
- Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.Circulation. 2017; 136: 65-79
- The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.Nat Commun. 2018; 9https://doi.org/10.1038/S41467-017-02431-1
- MALAT1 Modulates TGF-β1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145.Cell Physiol Biochem. 2017; 42: 357-372
- Long noncoding RNA MALAT1 sponges miR-124-3p.1/KLF5 to promote pulmonary vascular remodeling and cell cycle progression of pulmonary artery hypertension.Int J Mol Med. 2019; 44: 871-884
- LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1.Life Sci. 2019; 237https://doi.org/10.1016/J.LFS.2019.116769
- Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression.Eur J Pharmacol. 2020; 889https://doi.org/10.1016/J.EJPHAR.2020.173618
- LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2020; 319: H377-H391
- The lncRNA PAHRF functions as a competing endogenous RNA to regulate MST1 expression by sponging miR-23a-3p in pulmonary arterial hypertension.Vascul Pharmacol. 2021; 139https://doi.org/10.1016/J.VPH.2021.106886
- Long Noncoding RNA MEG3 Downregulation Triggers Human Pulmonary Artery Smooth Muscle Cell Proliferation and Migration via the p53 Signaling Pathway.Cell Physiol Biochem. 2017; 42: 2569-2581
- HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.Am J Pathol. 2001; 158: 955-966
- LncRNA HOXA-AS3 Promotes the Progression of Pulmonary Arterial Hypertension through Mediation of miR-675-3p/PDE5A Axis.Biochem Genet. 2021; 59: 1158-1172
- Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation.Cardiovasc Res. 2019; 115: 647-657
- VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling.Circ Res. 2010; 107: 408-417
- TUG1 Regulates Pulmonary Arterial Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension.Can J Cardiol. 2019; 35: 1534-1545
- Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin.Mol Ther Nucleic Acids. 2018; 13: 44-54
- LncRNA-Ang362 Promotes Pulmonary Arterial Hypertension by Regulating miR-221 and miR-222.Shock. 2020; 53: 723-729
- The Long Noncoding RNA LnRPT Is Regulated by PDGF-BB and Modulates the Proliferation of Pulmonary Artery Smooth Muscle Cells.Am J Respir Cell Mol Biol. 2018; 58: 181-193
- Long Noncoding RNA Rps4l Mediates the Proliferation of Hypoxic Pulmonary Artery Smooth Muscle Cells.Hypertension. 2020; 76: 1124-1133
- lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation and inhibits the proliferation of PASMCs caused by hypoxia.Mol Ther. 2021; 29: 1411-1424
- Long noncoding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.Biomed Pharmacother. 2019; 115https://doi.org/10.1016/J.BIOPHA.2019.108933
- Metformin inhibits pulmonary artery smooth muscle cell proliferation by upregulating p21 via NONRATT015587.2.Int J Mol Med. 2022; 49https://doi.org/10.3892/IJMM.2022.5104
- Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ.Am J Respir Crit Care Med. 2020; 202: 1445-1457
- Long noncoding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1.J Pathol. 2019; 247: 357-370
- LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis.J Cell Mol Med. 2021; 25: 7321-7334
- LncRNA-TCONS_00034812 in cell proliferation and apoptosis of pulmonary artery smooth muscle cells and its mechanism.J Cell Physiol. 2018; 233: 4801-4814
- Long Noncoding RNA-Maternally Expressed Gene 3 Contributes to Hypoxic Pulmonary Hypertension.Mol Ther. 2019; 27https://doi.org/10.1016/J.YMTHE.2019.07.022
- Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21.Biochem Biophys Res Commun. 2018; 495: 2125-2132
- Long noncoding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension.Respir Res. 2019; 20https://doi.org/10.1186/S12931-019-1018-X
- Downregulation of long noncoding RNA ANRIL promotes proliferation and migration in hypoxic human pulmonary artery smooth muscle cells.Mol Med Rep. 2020; 21: 589-596
- LincRNA-Cox2 promotes pulmonary arterial hypertension by regulating the let-7a-mediated STAT3 signaling pathway.Mol Cell Biochem. 2020; 475: 239-247
- Circulating miRNAs as potential marker for pulmonary hypertension.PLoS One. 2013; 8https://doi.org/10.1371/JOURNAL.PONE.0064396
- Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension.Pediatr Crit Care Med. 2020; 21: 340-349
- Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.Circulation. 2020; 142: 1464-1484
- Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers.Sci Rep. 2016; 6https://doi.org/10.1038/SREP36596
- Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells.Pflugers Archiv Eur J Physiol. 2019; 471: 347-355
- LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension.Respir Res. 2018; 19: 1-18
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